
There is also a risk that adults with hypophosphatasia will be affected by dental problems. In patients with hypophosphatasia who are not diagnosed until adulthood, the periodontal element of the disease will often have been pronounced since childhood.

Tooth-loosening of intact deciduous teeth with root
Reibel A et al. 2009
Other tooth-related problems may include:
- Enlarged pulp chambers and root canals
- Abnormal enamel and dentin formation
- Deviations in tooth shape, structure and eruption
Kjellman M et al. Int J Oral Surg 1973; 2: 152-158.
Lundgren T et al. Scand J Dent Res 1991; 99: 357-364.
Olsson A et al. J Oral Pathol Med 1996; 25: 343-347.
Reibel A et al. Orphanet J Rare Dis 2009; 4: 6.
Van den Bos T et al. J Dent Res 2005; 84: 1021-1025.
