Muscle and joint-related and rheumatological manifestations can affect patients throughout their lives. Calcification of soft tissue and joints is common with hypophosphatasia and complications include:
- Muscle weakness
- Chronic pain
- Chondrocalcinosis
- Pseudogout
- Osteoarthropathy
- Arthritis
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Chuck AJ et al. Ann Rheum Dis 1989; 48: 571-576.
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Seshia SS et al. Arch Dis Child 1990; 65: 130-131.
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