Neurological manifestations are among the most serious for paediatric patients with hypophosphatasia. These neurological manifestations can, for example, be:
- Vitamin B6-related seizures
- Epileptic encephalopathy
- Craniosynostosis with associated complications such as increased intracranial pressure, optic nerve damage and/or papilloedema

Beaten copper appearance and craniosynostosis
Rockman-Greenberg C. 2013
Impaired growth can also lead to neurological consultation. Children with hypophosphatasia often exhibit delayed motor development or completely missed motor milestones.
In infants, vitamin B6-related seizures are an poor prognostic sign and are related to mortality in most cases.
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