Respiratory manifestations of hypophosphatasia can be life-threatening. Breathing complications may consist of anything from progressive pneumonia to respiratory failure as a consequence of reduced thoracic volume and pulmonary hypoplasia. Respiratory failure is the most common cause of death in infants with hypophosphatasia.In patients with hypophosphatasia, respiratory manifestations can lead to:
- Insufficient respiration that requires intubation, mechanical ventilation and/or oxygen
- Lung inflammation and respiratory failure
Lung insufficiency that requires a tracheostomy tube
Hickman Simmons J 2013
Hypomineralisation of ribs
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