
In patients with hypophosphatasia, respiratory manifestations can lead to:
- Insufficient respiration that requires intubation, mechanical ventilation and/or oxygen
- Lung inflammation and respiratory failure

Lung insufficiency that requires a tracheostomy tube
Hickman Simmons J 2013

Hypomineralisation of ribs
Rodriguez E et al. 2012
Leung EC et al. JIMD Rep 2013; 11: 73-78.
Hickman Simmons, J. Best Practices In: Recognizing and Diagnosing Hypophosphatasia. Clinical Endocrinology News. 2013; 1-8.
Rodriguez E et al. Pediatr Pulmonol. 2012; 47 (9):917-922
Silver et al. MM Pediatr Pathol 1988; 8: 483-493.
Whyte MP et al. N Engl J Med 2012; 366: 904-913.
